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  "documentTitle": "Chimerix | Investor Presentation Deck | 43 slides",
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  "authorName": "Chimerix",
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  "presentationDate": "2023-08-01 00:00:00",
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  "notes": "Includes a detailed biological pathway diagram showing mitochondrial and membrane-level interactions.",
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      "text": "Biological pathway diagram showing ONC201 interaction with DRD2 and ClpP",
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      "text": "ONC201 can selectively induce apoptosis in cancer cells by altering the activity of two protein targets. DRD2 antagonism: DRD2 is a G protein-coupled neuroreceptor that regulates Ras signaling; ONC201 antagonizes DRD2, inhibiting Ras signaling pathways. ClpP agonism: ClpP normally degrades misfolded proteins in mitochondria; ONC201 modifies ClpP conformation, promoting excess degradation of specific mitochondrial proteins important for cancer cell viability.",
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      "text": "ClpP=caseinolytic protease P; OXPHOS=oxidative phosphorylation; DRD2=Dopamine receptor D2; ATF4=activating transcription factor 4; CHOP=C/EBP-homologous protein; ERK=extracellular-regulated kinase;",
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      "text": "ONC201 upregulates integrated stress response, inactivates Akt/ERK, and selectively induces tumor cell death",
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      "text": "ONC201 directly engages DRD2 and ClpP",
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