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  "documentTitle": "Exscientia | Investor Presentation Deck | 73 slides",
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      "text": "Bilirubin is made during the natural degradation of red blood cells. It is rapidly cleared from the body, mainly through liver metabolism and subsequent biliary elimination. Uptake of unconjugated bilirubin into the liver occurs in part via OATP transport. Once in the liver, bilirubin is exclusively glucuronidated by UGT1A1, and then effluxed into the bile by MRP2. UGT1A1 inhibition can cause elevated bilirubin (hyperbilirubinemia) and can lead to metabolic disorder. Jaundice, nausea, vomiting and potentially encephalopathy can occur. The UGT1A1 pathway has an active role in triggering potential drug-drug interactions in the clinic. This is particularly relevant to BTKi given the many reports of drug-induced liver injury with these agents",
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      "text": "Avoiding uridine glucuronyl transferase (UGT1A1)",
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