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  "notes": "Includes a biological pathway diagram and Western blot data comparing a degrader (KT-253) to an inhibitor (DS-3032).",
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      "text": "MDM2 SMI's show activity, but can induce feedback loop, limiting impact on pathway. MDM2 degraders remove the protein, can overcome the p53-dependent feedback loop that upregulates MDM2. By inducing an acute apoptotic response in tumor cells, degraders can increase efficacy and therapeutic index vs a small molecule inhibitor.",
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