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  "documentTitle": "Kymera | Investor Presentation Deck | 60 slides",
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  "authorName": "Kymera",
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  "presentationDate": "2023-06-01 00:00:00",
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  "notes": "The diagram illustrates the signaling pathways (TLR, IL-1R, B Cell Receptor) and the specific points of intervention (red asterisks) for the therapy.",
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      "kind": "diagram",
      "text": "Pathway diagram showing TLR, IL-1R, and B Cell Receptor signaling leading to NFkB and IFN pathways, with red asterisks indicating therapeutic targets.",
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      "text": "Single-agent therapies targeting activated NFkB signaling in DLBCL show limited activity. Redundant NFkB pathway activation and downregulation of Type 1 IFN common in MYD88MT lymphoma. Simultaneous degradation of IRAK4 and IMiD substrates Ikaros and Aiolos shows synergistic activity in MYD88MT models.",
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      "text": "Source: Bionest and Global Data. ROW includes E.U., U.K. and Japan. Adapted from Yang et al. (2012) Cancer Cell 21, 6, pp723-737",
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      "text": "Prevalence and incidence data for MYD88 MT DLBCL, Waldenström’s Macroglobulinemia, and PCNS Lymphoma in U.S. and R.O.W.",
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      "kind": "title",
      "text": "IRAKIMiDs are Potent Degraders of IRAK4 and IMiD Substrates Targeting Redundant Pro-survival Pathways in MYD88MT DLBCL",
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