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  "documentTitle": "Kymera | Investor Presentation Deck | 60 slides",
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  "authorName": "Kymera",
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  "presentationDate": "2023-06-01 00:00:00",
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  "notes": "HS = Hidradenitis Suppurativa; AD = Atopic Dermatitis; HV = Healthy Volunteers; MAD = Multiple Ascending Dose; LLOQ = Lower Limit of Quantitation.",
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      "text": "IRAK4 Levels in PBMC in Patients at Day 28 (MS)",
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      "text": "Part C KT-474 Plasma PK",
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      "text": "KT-474 concentrations in plasma lead to same level of IRAK4 degradation in HV (n=48) and HS/AD (n=20) patients. Concentrations above 3 ng/mL lead to same level of degradation (>80%) in HV and Patients.",
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      "text": "KT-474 PK at the 75 mg QD dose (fed state) in patients is comparable to 100 mg QD (fasted state) in HV. Mean Cmax and Ctrough levels at steady state in Part C are in line with MAD3 levels at Day 14. Mean half-life of 44 hours is within range.",
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