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  "notes": "Includes a structural biology visualization of the Orexin 2 receptor.",
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      "text": "Orexin 2 Receptor in Complex with Peptide-Agonist Orexin-B",
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      "text": "ALKS 2680 molecular design objectives: Capture performance of endogenous peptide OX2R agonist (Increased wakefulness duration, Improved cataplexy control); Optimize potency; Provide PK/PD profile; Enable once-daily oral medication.",
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      "text": "Figure adapted from: Hong, Chuan, et al. Nature communications. 2021:12; 3. PDB ID: 7L1U",
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      "text": "Leveraging Alkermes' Molecular Design Capabilities to Target Orexin Dysfunction",
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