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  "documentTitle": "Alkermes | Investor Presentation Deck | 56 slides",
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  "presentationDate": "2023-06-01 00:00:00",
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  "notes": "Includes a diagram of brain pathways related to wakefulness and neurotransmitters.",
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      "text": "Diagram of brain pathways showing Orexin (hypothalamus) connections to wakefulness, nucleus accumbens, ventral tegmental area, raphe nuclei, and locus coeruleus.",
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      "text": "In narcolepsy and other sleep disorders, low orexin levels lead to inconsistent neurotransmitter release, resulting in excessive sleepiness and poor regulation of REM sleep. Narcolepsy affects ~200,000 people in U.S. and 3M people globally. 70% of people with narcolepsy have narcolepsy type 1, distinguished by: Cataplexy, a sudden muscle weakness triggered by strong emotions; Low or no orexin in the brain. Genetic and pharmacologic evidence suggests that orexin receptor agonists, especially OX2R agonists, may be useful for mechanistic therapy of narcolepsy.",
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      "text": "ALKS 2680 molecular design objectives:",
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      "text": "1 Global Narcolepsy Drugs Market, Forecast 2019-2025. Allied Market Research. 2 Swick TJ. Treatment paradigms for cataplexy in narcolepsy: past, present, and future. Nat Sci Sleep. 2015;7:159-169. 3 Nagahara T. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J. Med. Chem. 2015;58:7931-7937",
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      "text": "Orexin Dysfunction: Well Defined Opportunity in Narcolepsy and Other Sleep Disorders",
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