{
  "docId": "019de075-03fc-75b4-9b20-1ad4baba72b2",
  "docSlug": "9cc11288f450409d9a3eef75fc694943",
  "documentTitle": "Nuvalent | Investor Presentation Deck | 39 slides",
  "authorId": "nuvalent",
  "authorName": "Nuvalent",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-05-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 27,
  "pageCount": 39,
  "prevPage": 26,
  "nextPage": 28,
  "slideType": "solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 1,
  "notes": "The slide uses a list format to define the TPP, which is a standard pharmaceutical industry framework.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de075-03fc-75b4-9b20-1ad4baba72b2/27",
  "deckHref": "/decks/019de075-03fc-75b4-9b20-1ad4baba72b2",
  "deckJsonHref": "/decks/019de075-03fc-75b4-9b20-1ad4baba72b2.json",
  "deckAnchorHref": "/decks/019de075-03fc-75b4-9b20-1ad4baba72b2#slide-27",
  "components": [
    {
      "bbox": {
        "h": 0.55,
        "w": 0.05,
        "x": 0.512,
        "y": 0.265
      },
      "kind": "image",
      "text": null,
      "attrs": null,
      "subkind": "icon-grid",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5f6da082-7bd6-4de8-8669-49f219fa467b",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.38,
        "x": 0.586,
        "y": 0.418
      },
      "kind": "list",
      "text": "Active against treatment-emergent ALK G1202R single and compound resistance mutations e.g., G1202R/L1196M, G1202R/G1269A, G1202R/L1198F",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "15acece4-8aec-4b0a-aad3-75fac643a46d",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.35,
        "x": 0.586,
        "y": 0.578
      },
      "kind": "list",
      "text": "Brain penetrant ~30 – 40% of patients with ALK-positive NSCLC present with brain metastases",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "564cd30f-077a-4cad-a0fb-9b74e5b6d9d7",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.35,
        "x": 0.586,
        "y": 0.292
      },
      "kind": "list",
      "text": "Active against wild-type ALK fusions",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a0bf262e-61ca-4a0f-aa19-51c5077d66f7",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.35,
        "x": 0.586,
        "y": 0.752
      },
      "kind": "list",
      "text": "TRK sparing to minimize CNS adverse events",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b9887ad4-006f-4109-8572-4d3df31fc337",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.7,
        "w": 0.33,
        "x": 0.106,
        "y": 0.318
      },
      "kind": "title",
      "text": "NVL-655 for ALK-Positive Advanced NSCLC and Other Solid Tumors",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "db058d34-6e31-47ef-b656-7fda04752a2e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.25,
        "x": 0.512,
        "y": 0.188
      },
      "kind": "title",
      "text": "TARGET PRODUCT PROFILE:",
      "attrs": null,
      "subkind": "subtitle",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "51b4c697-1082-49e6-b9dd-ef6bd83e15cb",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "Target Product Profile",
      "slug": null,
      "matchId": "0d1649c0-65c1-4b5b-95fd-441363886589",
      "evidence": "Standard pharmaceutical development framework for defining drug characteristics",
      "confidence": 1
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}