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  "documentTitle": "Compass Therapeutics | Investor Presentation Deck | 40 slides",
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  "authorName": "Compass Therapeutics",
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  "notes": "Clinical trial data summary for CTX-009.",
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      "text": "Phase 1 Results",
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      "text": "Safety: well-tolerated; MTD has not been determined\nActivity: 8 PRs, 6 confirmed by RECIST in 33 advanced solid tumor patients treated\nResponses as a monotherapy: colorectal and gastric\nResponses in combination with chemotherapy: cholangiocarcinoma, pancreatic\nCholangio ORR= 50%; Clinical benefit rate = 75% with a median duration of response of 9.7 months",
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      "text": "N=45: Gastric, CRC, Other\nNine dose-escalation cohorts (0.3-17.5 mg/kg)\nFour dose-expansion cohorts (7.5-15 mg/kg)",
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      "text": "N=17: 4 arms\n1. CTX-009 10.0 mg/kg + paclitaxel\n2. CTX-009 10.0 mg/kg + irinotecan\n3. CTX-009 12.5 mg/kg + paclitaxel\n4. CTX-009 12.5 mg/kg + irinotecan",
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      "text": "Phase 1a: dose-escalation monotherapy study",
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      "text": "Phase 1b: combination study with chemotherapy",
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