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  "documentTitle": "Chimerix | Investor Presentation Deck | 41 slides",
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  "presentationDate": "2023-05-01 00:00:00",
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  "notes": "Data presented includes ORR, DOR, time to response, disease control rate, PFS, and overall survival metrics.",
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      "text": "ONC201 monotherapy exhibited durable, clinically meaningful efficacy in recurrent H3 K27M-mutant DMG",
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      "text": "Overall survival: 12 months: 57% (95% CI:41 – 70%); 24 months: 35% (95% CI: 21 – 49%)",
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      "text": "RANO-HGG criteria assessed by dual reader BICR: ORR 20%, DOR 11.2 months, time to response 8.3 months, disease control 40%, PFS 6mo 35%, PFS 12mo 30%",
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      "text": "RANO-LGG criteria assessed by dual reader BICR: ORR 26% (95% CI: 15 – 40%)",
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      "text": "Improvements observed in performance status and reduction in corticosteroid use",
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      "text": "All SAEs considered not related to ONC201 by sponsor",
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