{
  "docId": "019de074-ddab-749d-b286-5e01e8bcb935",
  "docSlug": "f43e68719e672319f390e5844d5bc5fe",
  "documentTitle": "Chimerix | Investor Presentation Deck | 41 slides",
  "authorId": "chimerix",
  "authorName": "Chimerix",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-05-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 6,
  "pageCount": 41,
  "prevPage": 5,
  "nextPage": 7,
  "slideType": "problem_statement",
  "function": "frame_problem",
  "density": "overcrowded",
  "nDataPoints": 14,
  "notes": "Includes Kaplan-Meier survival curves and a comparative table of clinical outcomes.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de074-ddab-749d-b286-5e01e8bcb935/6",
  "deckHref": "/decks/019de074-ddab-749d-b286-5e01e8bcb935",
  "deckJsonHref": "/decks/019de074-ddab-749d-b286-5e01e8bcb935.json",
  "deckAnchorHref": "/decks/019de074-ddab-749d-b286-5e01e8bcb935#slide-6",
  "components": [
    {
      "bbox": {
        "h": 0.35,
        "w": 0.48,
        "x": 0.02,
        "y": 0.55
      },
      "kind": "chart",
      "text": "External analysis reported at SNO 2022",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3fa8f8c7-3d0e-40f9-8256-83a2d7901d74",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.35,
        "w": 0.35,
        "x": 0.58,
        "y": 0.15
      },
      "kind": "image",
      "text": "Histone H3 Mutations in CNS Tumors",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4fd7f391-9378-40c6-95dd-e48d9a3ebae9",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.35,
        "w": 0.48,
        "x": 0.02,
        "y": 0.15
      },
      "kind": "list",
      "text": "H3 K27M mutation is predominantly found among diffuse midline gliomas (DMGs) in young adults and children. Frontline radiotherapy remains standard of care with transient benefit; resection often not feasible. DMGs harboring the H3 K27M mutation are WHO Grade IV; historically invariably lethal. Studies consistently indicate longer OS of ONC201-treated glioma patients relative to diverse external controls.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "00465b69-3528-4e4e-8bab-da0a8c3b2f03",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.08,
        "w": 0.9,
        "x": 0.05,
        "y": 0.92
      },
      "kind": "source-note",
      "text": "Lulla RR et al. Sci Adv. 2016;2(3):e1501354; Sunjong Ji, B.S. et al, “Clinical efficacy and predictive biomarkers of ONC201 in H3 K27M-mutant diffuse midline glioma”, Society of Neuro-oncology 2022",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5671ce87-59c8-454d-a50e-717ce896ae7f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.35,
        "w": 0.45,
        "x": 0.53,
        "y": 0.55
      },
      "kind": "table",
      "text": "Company Sponsored Studies",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "422b8701-5fda-4fee-bf9e-7eaeec6fb4d4",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.68,
        "x": 0.16,
        "y": 0.05
      },
      "kind": "title",
      "text": "H3 K27M-mutant diffuse glioma: high unmet need",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "984d6492-70ae-4c55-93dc-c271a8290914",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 6,
      "from": 6,
      "beatId": "350ef670-de6c-4b45-8ced-2b5bb89b1777",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Problem Statement",
      "beatSlug": null,
      "evidence": "The deck clearly states the problem of H3 K27M-mutant diffuse glioma",
      "position": 0,
      "confidence": 0.8,
      "parentBeatName": null,
      "parentBeatSlug": null
    }
  ],
  "loops": [
    {
      "to": 14,
      "from": 6,
      "name": "Cost Of Inaction",
      "slug": "27-cost-of-inaction",
      "bestFor": "Urgent budget requests, compliance, risk mitigation",
      "matchId": "77a4ca89-6944-4b59-9557-b7e1ac4d70e5",
      "evidence": "The deck presents data on the unmet need and potential benefits of ONC201",
      "position": 0,
      "objective": "Highlight the cost of inaction in treating H3 K27M-mutant diffuse glioma",
      "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
      "confidence": 0.7,
      "description": "Quantify what happens if the audience does nothing"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}