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  "notes": "The chart shows a dose-response curve where longer incubation times (48+ hours) shift the curve to the left compared to 24 hours, indicating higher potency/efficacy with sustained exposure.",
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      "text": "Cell viability vs ONC201 concentration for different incubation times",
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      "text": "Once per week ONC201 dosing effective as monotherapy in Phase 2 studies. Twice per week dosing on two consecutive days expected to increase duration of therapeutic exposure. Phase 3 ACTION study will evaluate once per week and twice per week dosing.",
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