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  "notes": "Includes testimonials from KOLs to emphasize the difficulty of patient compliance.",
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      "text": "With Persistently High Total Homocysteine Levels, Patients Remain at Risk for Serious and Life-Threatening Complications",
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      "text": "Compliance with severe dietary restrictions and amino acid supplementation is extremely challenging and represents a lifelong burden. Vitamin B6 is largely ineffective at lowering tHcy to guidance levels for the majority of patients. Betaine can be associated with both safety and tolerability issues such as hypermethioninemia, nausea, gastrointestinal distress, and body odor.",
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      "text": "For patients with Classical Homocystinuria, [the biggest challenge] would be compliance with diet. - U.S. Key Opinion Leader",
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