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  "documentTitle": "Aeglea BioTherapeutics | Investor Presentation Deck | 37 slides",
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  "presentationDate": "2023-04-01 00:00:00",
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  "notes": "Includes two testimonials from Key Opinion Leaders (KOLs) to emphasize the patient burden.",
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      "kind": "callout",
      "text": "With Persistently High Total Homocysteine Levels, Patients Remain at Risk for Serious and Life-Threatening Complications",
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      "text": "Hand holding a large number of pills",
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      "text": "Compliance with severe dietary restrictions and amino acid supplementation is extremely challenging and represents a lifelong burden\nVitamin B6 is largely ineffective at lowering tHcy to guidance levels for the majority of patients\nBetaine can be associated with both safety and tolerability issues such as hypermethioninemia, nausea, gastrointestinal distress, and body odor",
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      "text": "One patient's daily protein supplement, which is only one portion of his treatment regimen",
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      "kind": "quote",
      "text": "“For patients with Classical Homocystinuria, [the biggest challenge] would be compliance with diet.” - U.S. Key Opinion Leader",
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      "text": "“To get the family to cope with a very difficult life, and to have them compliant for life ... is a very big challenge.” - EU Key Opinion Leader",
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      "text": "tHcy = total homocysteine",
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      "text": "Patients with Classical HCU Live With Both Disease and Treatment Burden",
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