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  "documentTitle": "Aeglea BioTherapeutics | Investor Presentation Deck | 37 slides",
  "authorId": "aeglea-biotherapeutics",
  "authorName": "Aeglea BioTherapeutics",
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  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-04-01 00:00:00",
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  "notes": "ADA stands for Anti-Drug Antibodies.",
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      "kind": "callout",
      "text": "Additional cohorts could be used to explore higher doses, longer dosing duration, and the potential to dose through the impact of ADAs",
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      "text": "Efficacy: Data from Phase 1/2 clinical trial indicated pegtarviliase is capable of lowering homocysteine levels. Results from cohort 3 did not show consistent homocysteine lowering, likely due to the presence of ADAs. ADAs frequently seen with other pegylated enzyme therapies; potential to dose through pharmacological impact",
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      "text": "Safety: Adverse events have been mild to moderate in data gathered to date. Toxicology data indicates a large dosing window and potential to continue dose escalation. Manufacturing: Stable, high-concentration liquid formulation. Regulatory: Orphan Disease, Fast Track and Rare Pediatric Disease designations for Homocystinuria",
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      "kind": "title",
      "text": "Pegtarviliase Program Summary",
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      "evidence": "The document presents Pegtarviliase as a solution to lower homocysteine levels",
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