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  "docSlug": "e0247ed9fbf6e59fd6aeeea6f3eacc2d",
  "documentTitle": "23andMe | Investor Presentation Deck | 57 slides",
  "authorId": "23andme",
  "authorName": "23andMe",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-04-01 00:00:00",
  "orientation": "landscape",
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  "pageNumber": 42,
  "pageCount": 57,
  "prevPage": 41,
  "nextPage": 43,
  "slideType": "solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 1,
  "notes": "The slide uses a before-and-after diagram to illustrate the mechanism of action.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de074-a4f4-74e1-8870-171c8951fea8/42",
  "deckHref": "/decks/019de074-a4f4-74e1-8870-171c8951fea8",
  "deckJsonHref": "/decks/019de074-a4f4-74e1-8870-171c8951fea8.json",
  "deckAnchorHref": "/decks/019de074-a4f4-74e1-8870-171c8951fea8#slide-42",
  "components": [
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      "bbox": {
        "h": 0.05,
        "w": 0.35,
        "x": 0.01,
        "y": 0.93
      },
      "kind": "disclaimer",
      "text": "*CD200-expressing cell types include tumor, stroma and endothelial\nIFN, interferon; IL, interleukin",
      "attrs": null,
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      "kind": "image",
      "text": "Mechanism of action diagram showing T-cell activation by blocking CD200R1",
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      "kind": "list",
      "text": "23ME ’610 is a fully humanized, effectorless, IgG1 antibody against human CD200R1\n23ME ’610 binds CD200R1 with high affinity (KD < 0.1 nM)\n23ME ’610 blocks CD200 ligand binding to CD200R1, resulting in inhibition of immunosuppressive signaling\nThe restoration of T-cell activity by 23ME ’610 was demonstrated using in vitro models of the tumor microenvironment\nNo adverse effects of blocking CD200R1 have been observed in nonclinical toxicology studies",
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        "x": 0.03,
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      "kind": "title",
      "text": "23ME-00610 (23ME’610) Binds with High Affinity to CD200R1 and Inhibits Immunosuppressive Signaling",
      "attrs": null,
      "subkind": "headline",
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  "metrics": [],
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  "arcBeats": [],
  "loops": [
    {
      "to": 48,
      "from": 36,
      "name": "Quick Win Big Bet",
      "slug": "47-quick-win-big-bet",
      "bestFor": "Transformation planning, 100-day plans, resource allocation",
      "matchId": "25bf5fec-1759-4ae6-8d05-5ad619b628ea",
      "evidence": "The deck presents 23andMe's research and development pipeline and its immuno-oncology programs",
      "position": 2,
      "objective": "What are the opportunities for 23andMe in therapeutics development?",
      "structure": "The Full List -> Quick Wins (Low effort, High impact) -> Big Bets (High effort, High impact) -> Sequenced Roadmap",
      "confidence": 0.6,
      "description": "Separate initiatives into immediate wins and longer-term strategic bets"
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