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      "text": "Contrast estimate for Placebo vs 300mg BNC210",
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      "text": "Connectivity between the amygdala and Anterior Cingulate Cortex (ACC) is very strong in high anxiety. BNC210 reduced connectivity between amygdala and ACC while viewing fearful faces (p=0.012)",
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      "text": "Amygdala activation is an imaging surrogate for anxiety. BNC210 reduced activation of L & R amygdala caused by viewing fearful faces (L: p=0.011; R: p=0.006)",
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      "text": "BNC210 300 mg significantly reduced self-reported state anxiety - STAI (p=0.003). BNC210 300 mg and 2000 mg reduced threat avoidance behavior of anxious subjects in the JORT behavioral task",
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      "text": "BNC210; Wise T. et al., Biological Psychiatry 2020; Perkins A. et al., Translational Psychiatry 2021; JORT = Joystick Operated Runway Task",
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