{
  "docId": "019de074-7a94-707c-b002-278357aaec02",
  "docSlug": "fb2ab974265a0e95c40d5a8a75128cd1",
  "documentTitle": "BenevolentAI | Results Presentation Deck | 38 slides",
  "authorId": "benevolentai",
  "authorName": "BenevolentAI",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-03-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 32,
  "pageCount": 38,
  "prevPage": 31,
  "nextPage": 33,
  "slideType": "other",
  "function": "illustrate_case",
  "density": "overcrowded",
  "nDataPoints": 12,
  "notes": "The slide uses a flow-chart to represent an adaptive clinical trial design.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de074-7a94-707c-b002-278357aaec02/32",
  "deckHref": "/decks/019de074-7a94-707c-b002-278357aaec02",
  "deckJsonHref": "/decks/019de074-7a94-707c-b002-278357aaec02.json",
  "deckAnchorHref": "/decks/019de074-7a94-707c-b002-278357aaec02#slide-32",
  "components": [
    {
      "bbox": {
        "h": 0.12,
        "w": 0.25,
        "x": 0.08,
        "y": 0.78
      },
      "kind": "callout",
      "text": "Phase Ib: Successfully completed Safety and Tolerability arm",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2e30477a-e578-4a5d-b55d-a42790c2d31a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.6,
        "w": 0.55,
        "x": 0.38,
        "y": 0.25
      },
      "kind": "diagram",
      "text": "Adaptive design for Phase Ib of the clinical study",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c4862774-1779-46df-9cd6-c9c53954d363",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.3,
        "x": 0.05,
        "y": 0.25
      },
      "kind": "diagram",
      "text": "Phase Ib dose escalation timeline",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d84f3fe2-b29f-43b6-a138-a6bf8e54b7f2",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.3,
        "x": 0.05,
        "y": 0.6
      },
      "kind": "list",
      "text": "Safety, Tolerability, PK: Adaptive multiple ascending dose cohort design, Includes efficacy endpoints, MALDI imaging",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2d11c6ea-6516-4545-a24d-525b94328c4c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.3,
        "x": 0.05,
        "y": 0.4
      },
      "kind": "list",
      "text": "Phase Ib completed Dec 2021; 8 Mild-Moderate AD patients per cohort, randomised 3:1 BEN-2293:Placebo",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "db2fb38a-437d-4d55-bd68-5598df24b413",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.4,
        "x": 0.05,
        "y": 0.95
      },
      "kind": "source-note",
      "text": "BSA= Body surface area. QD = once per day dosing BID= twice per day dosing",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9b6994cd-fd1d-42a2-98c9-3f4301a78dc4",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.7,
        "x": 0.05,
        "y": 0.05
      },
      "kind": "title",
      "text": "BEN-2293 - Phase Ib safety and tolerability study successfully completed",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8bef6bc7-9b60-4808-a76e-7ad1ec583573",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.8,
        "x": 0.05,
        "y": 0.15
      },
      "kind": "title",
      "text": "Phase Ib/IIa double-blind, placebo-controlled, first-in-patient, two-part clinical study",
      "attrs": null,
      "subkind": "subtitle",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9dc89cb1-4c50-489d-a428-98320cf88adf",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "Adaptive Clinical Trial Design",
      "slug": null,
      "matchId": "6f5aaef5-ec09-4297-8e11-4ebcdc58b680",
      "evidence": "Flowchart showing cohort progression based on tolerability outcomes",
      "confidence": 0.9
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}