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  "documentTitle": "Arbutus Biopharma | Investor Presentation Deck | 28 slides",
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      "text": "AB-101 is advancing into Phase 1 clinical trial in 1H 2023",
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      "text": "Small-Molecule Inhibitor Approach: Allows controlled checkpoint blockade; Enables oral dosing; Designed to reduce systemic safety issues seen with Abs.",
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      "text": "AB-101: Blocks PD-L1/PD-1 interaction; Activates HBV-specific immune responses; Novel MOA identified; Demonstrates robust checkpoint mediated in vivo effect; Improves HBV-specific T- and B-cell responses.",
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      "text": "Rationale: HBV immune tolerance is a critical driver of cHBV infection; PD-1:PD-L1 checkpoint axis plays a key role; PD-L1 expression upregulated; PD-1 upregulated; Inhibition associated with HBsAg loss.",
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