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  "documentTitle": "Aeglea BioTherapeutics | Investor Presentation Deck | 39 slides",
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      "text": "There are no approved disease-modifying treatments for HCU, i.e., addressing high levels of homocysteine. Toxic levels of homocysteine can lead to sudden catastrophic events, including death. Manifestations, which are often irreversible, can occur in early childhood and worsen over time",
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      "text": "Eyes: Lens dislocation, glaucoma, severe near-sightedness. Nervous System: Intellectual and developmental delays, behavioral abnormalities, seizures. Vascular: Life-threatening thrombotic events, heart attack, stroke. Skeletal: Long bone (Marfanoid) features, skeletal deformities, osteoporosis",
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      "text": "Classical Homocystinuria (HCU) Also known as cystathionine beta synthase (CBS) deficiency, Classical Homocystinuria is a serious and progressive metabolic disorder characterized by elevated levels of the amino acid homocysteine.",
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      "text": "Betaine, approved by the FDA in 1996, can lower homocysteine levels in the blood through remethylation to methionine but does not metabolize homocysteine and clear it from the body",
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