{
  "docId": "019de074-704c-735b-b7a3-613838aa1bf3",
  "docSlug": "9b81d8a09c69afc3f139dc970effabde",
  "documentTitle": "Aeglea BioTherapeutics | Investor Presentation Deck | 39 slides",
  "authorId": "aeglea-biotherapeutics",
  "authorName": "Aeglea BioTherapeutics",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-03-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 36,
  "pageCount": 39,
  "prevPage": 35,
  "nextPage": 37,
  "slideType": "context",
  "function": "establish_context",
  "density": "overcrowded",
  "nDataPoints": 1,
  "notes": "The slide uses standard clinical metrics for motor function assessment.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de074-704c-735b-b7a3-613838aa1bf3/36",
  "deckHref": "/decks/019de074-704c-735b-b7a3-613838aa1bf3",
  "deckJsonHref": "/decks/019de074-704c-735b-b7a3-613838aa1bf3.json",
  "deckAnchorHref": "/decks/019de074-704c-735b-b7a3-613838aa1bf3#slide-36",
  "components": [
    {
      "bbox": {
        "h": 0.22,
        "w": 0.52,
        "x": 0.38,
        "y": 0.18
      },
      "kind": "image",
      "text": "GMFCS levels I-IV illustration",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c48a796a-af05-48fa-8d8c-c34d905c98f6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.4,
        "x": 0.12,
        "y": 0.72
      },
      "kind": "image",
      "text": "Patient walking photos",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "47e31926-c0b5-47f4-958f-80f4d6cce26a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.12,
        "x": 0.77,
        "y": 0.7
      },
      "kind": "image",
      "text": "Patient walking with crutches photo",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b056657e-bbad-4f34-918c-685db0345e82",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.45,
        "x": 0.03,
        "y": 0.56
      },
      "kind": "paragraph",
      "text": "Gross Motor Function Measure (GMFM) Part E Assesses unaided mobility without bracing or assistive devices. 24 tasks involving walking forward/backward, running, jumping and ascending/descending stairs with a score range of 0-72",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3ac86bd5-c4ca-49ef-9c83-c4f7402bb111",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.35,
        "x": 0.55,
        "y": 0.56
      },
      "kind": "paragraph",
      "text": "Timed Walk Tests Evaluates aided mobility with any needed bracing or assistive devices over a defined period of time: 2 mins (2MWT), 6 mins (6MWT)",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a9883572-f74f-4e0c-b0be-43451a1ea3a3",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.3,
        "x": 0.03,
        "y": 0.22
      },
      "kind": "paragraph",
      "text": "Gross Motor Function Classification System (GMFCS) Overall description of current motor function based on: Movements such as sitting, walking, Use of mobility devices",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f823ad16-53c0-4cd7-be75-b575fbf582b0",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.55,
        "x": 0.22,
        "y": 0.96
      },
      "kind": "source-note",
      "text": "GMFCS graphic adapted with permission from The Royal Children's Hospital Melbourne, Australia",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8e8b4bf8-68c9-4587-92c2-3aa7f435711f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.3,
        "x": 0.03,
        "y": 0.51
      },
      "kind": "title",
      "text": "Measures of Change in Mobility:",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "23a2202f-a7f3-4e26-be5e-065d87159b74",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.25,
        "x": 0.03,
        "y": 0.17
      },
      "kind": "title",
      "text": "Classification of Mobility:",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b94b2ff3-f83b-42e2-8ea0-79d6b518973f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.6,
        "x": 0.06,
        "y": 0.04
      },
      "kind": "title",
      "text": "Measuring the Functional Impact of Spasticity in ARG1-D",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "fb49c5c5-8b33-44d3-a0ff-5b1974ba5685",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Audience Definition",
      "slug": "audience-definition",
      "agent": "Storyteller",
      "layer": "slide",
      "matchId": "d68e4e5f-1c69-4545-98ce-b513d9a7d87a",
      "evidence": "paragraph/paragraph: Gross Motor Function Measure (GMFM) Part E Assesses unaided mobility without bracing or assistive devices.",
      "confidence": 0.5
    }
  ],
  "frameworks": [
    {
      "name": "maturity-model",
      "slug": null,
      "matchId": "7fffc14a-ac3c-475c-b551-fd791c0a411e",
      "evidence": "GMFCS levels represent a progression of motor function impairment",
      "confidence": 0.8
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}