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  "documentTitle": "Aeglea BioTherapeutics | Investor Presentation Deck | 39 slides",
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  "presentationDate": "2023-03-01 00:00:00",
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      "text": "Classical HCU by B6 Responsiveness",
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      "text": "Over 80% of patients are unable to achieve total homocysteine levels <50 µM with B6 alone, the definition of B6 responsiveness. This translates into an estimated ~25,000 treatment candidates in global addressable markets, approximately 8,500 of whom are in the U.S., EU4, and UK",
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      "text": "29% Non-Responders and Partial Responders have experienced a thromboembolic event",
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      "text": "79% Non-Responders and Partial Responders have experienced a lens dislocation",
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      "text": "Although Non-Responders and Partial Responders are generally diagnosed earlier in life, that diagnosis typically occurs several years following presentation of initial symptoms",
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      "text": "Data on file. Adapted from Sellos-Moura et al 2020. 2 Kozich, Sokolova, Morris, et al. 2021. 3 Mudd, Skovby et al. 1985.",
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      "text": "Classical HCU: A Sizeable Patient Population at Serious Risk of Severe Complications",
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