{
  "docId": "019de074-6e40-7441-bfa0-d80627fc8d08",
  "docSlug": "25f3e01ba2b8d2af980e43ec911ed6e5",
  "documentTitle": "Absci | Investor Presentation Deck | 37 slides",
  "authorId": "absci",
  "authorName": "Absci",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-03-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 22,
  "pageCount": 37,
  "prevPage": 21,
  "nextPage": 23,
  "slideType": "traction",
  "function": "analyze_data",
  "density": "overcrowded",
  "nDataPoints": 2,
  "notes": "Includes a biological diagram of TLS and a Kaplan-Meier survival curve.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de074-6e40-7441-bfa0-d80627fc8d08/22",
  "deckHref": "/decks/019de074-6e40-7441-bfa0-d80627fc8d08",
  "deckJsonHref": "/decks/019de074-6e40-7441-bfa0-d80627fc8d08.json",
  "deckAnchorHref": "/decks/019de074-6e40-7441-bfa0-d80627fc8d08#slide-22",
  "components": [
    {
      "bbox": {
        "h": 0.3,
        "w": 0.4,
        "x": 0.55,
        "y": 0.35
      },
      "kind": "chart",
      "text": "Kaplan-Meier survival curve showing progression-free survival for High vs Low Ig Straining.",
      "attrs": null,
      "subkind": "line",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "bd2cd85e-14d9-4325-bbac-1023ada1e70a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.45,
        "w": 0.35,
        "x": 0.08,
        "y": 0.33
      },
      "kind": "image",
      "text": "Diagram of a tumor microenvironment showing B cells, T cells, macrophages, and plasma cells within a Tertiary Lymphoid Structure.",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "382e5ec7-e393-4ee2-9b80-999f262eb3d2",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.4,
        "x": 0.55,
        "y": 0.68
      },
      "kind": "list",
      "text": "The presence of TLS is associated with longer progression-free survival and better response to immune checkpoint inhibitors. Rapidly growing evidence illustrates correlation between TLS-derived antibodies in the tumor microenvironment and positive clinical outcomes. TLS-derived antibodies have been shown to be associated with apoptosis of cancer cells in patients.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9a41b970-64bd-4f71-b0e6-09d088ab17ec",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.4,
        "x": 0.05,
        "y": 0.78
      },
      "kind": "paragraph",
      "text": "Tertiary Lymphoid Structures (TLS) are centers of immune activity (B-cell proliferation and antibody production) that develop in chronically inflamed tissues such as tumors.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "6f28aa22-b581-4f9d-a225-cb3f70b1fc20",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.35,
        "x": 0.05,
        "y": 0.88
      },
      "kind": "source-note",
      "text": "Meylan, Maxime, et al. \"Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer.\" Immunity 55.3 (2022): 527-541.",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8be8f910-cbe3-475a-a8e1-9a928c619db8",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.92,
        "x": 0.04,
        "y": 0.08
      },
      "kind": "title",
      "text": "Antibodies selected in tertiary lymphoid structures bind to cancer cells and are associated with favorable clinical outcomes",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c8c3746f-3c03-4e8f-a3b7-26d49d30c7c2",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "List presentation",
      "slug": "list-presentation",
      "agent": null,
      "layer": "slide",
      "matchId": "b9413504-d72d-489b-9924-4cb3eab0cff2",
      "evidence": "list/bullet: The presence of TLS is associated with longer progression-free survival",
      "confidence": 0.7
    }
  ],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}