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  "documentTitle": "Recursion Pharmaceuticals | Investor Day Presentation Deck | 143 slides",
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  "authorName": "Recursion Pharmaceuticals",
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  "presentationDate": "2023-01-01 00:00:00",
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  "notes": "Includes a patient photo and source citations at the bottom.",
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      "kind": "image",
      "text": "Julia – living with CCM",
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      "text": "No approved drugs for CCM and no other potential therapeutic in industry-sponsored clinical development; Most patients receive no treatment or only symptomatic therapy; Surgical resection or stereotactic radiosurgery not always feasible because of location of lesion and is not curative",
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      "text": ">1 million patients worldwide live with these lesions today; Caused by loss of function mutation in one of three genes: CCM1 (60%), CCM2 (20%), and CCM3 (20%); Inherited autosomal dominant mutation in 30-40%; or sporadic; US symptomatic population is more than 5 times larger than other rare diseases like Cystic Fibrosis (>31k patients) and Spinal Muscular Atrophy (>33k patients)",
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      "text": "~360,000 Symptomatic US + EU5 patients",
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      "text": "Source: Angioma Alliance; Flemming KD, et al . Population-Based Prevalence of Cerebral Cavernous Malformations in Older Adults: Mayo Clinic Study of Aging. JAMA Neurol. 2017 Jul 1;74(7):801-805. doi: 10.1001/jamaneurol.2017.0439. PMID: 28492932; PMCID: PMC5647645 ; Spiegler S, et al Cerebral Cavernous Malformations: An Update on Prevalence, Molecular Genetic Analyses, and Genetic Counselling. Mol Syndromol. 2018 Feb;9(2):60-69. doi: 10.1159/000486292. Epub 2018 Jan 25. PMID: 29593473; PMCID: PMC5836221.",
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