{
  "docId": "019de074-3cc2-7451-b551-f16094d96b35",
  "docSlug": "3309edf11a92b656dd98b92129b54a19",
  "documentTitle": "Recursion Pharmaceuticals | Investor Day Presentation Deck | 143 slides",
  "authorId": "recursion-pharmaceuticals",
  "authorName": "Recursion Pharmaceuticals",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2023-01-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 57,
  "pageCount": 120,
  "prevPage": 56,
  "nextPage": 58,
  "slideType": "propose_solution",
  "function": "present_solution",
  "density": "overcrowded",
  "nDataPoints": 1,
  "notes": "The slide outlines a drug discovery workflow from target identification to preclinical validation.",
  "elementsJson": null,
  "metadataConfidence": 0.95,
  "imagePath": null,
  "slideHref": "/slides/019de074-3cc2-7451-b551-f16094d96b35/57",
  "deckHref": "/decks/019de074-3cc2-7451-b551-f16094d96b35",
  "deckJsonHref": "/decks/019de074-3cc2-7451-b551-f16094d96b35.json",
  "deckAnchorHref": "/decks/019de074-3cc2-7451-b551-f16094d96b35#slide-57",
  "components": [
    {
      "bbox": {
        "h": 0.35,
        "w": 0.26,
        "x": 0.03,
        "y": 0.525
      },
      "kind": "chart",
      "text": "Recursion Map heatmap showing gene correlations",
      "attrs": null,
      "subkind": "heatmap",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2ea14275-15d3-4f33-85e0-cc9af83c1922",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.15,
        "x": 0.74,
        "y": 0.62
      },
      "kind": "image",
      "text": "Mouse model illustration for immune engagement and inflammation",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "243d3d4c-fee4-46cb-bb4e-544994947df5",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.3,
        "w": 0.9,
        "x": 0.03,
        "y": 0.2
      },
      "kind": "list",
      "text": "1. Evaluation of 110 sensitization and resistance markers from public pooled CRISPR screens in the Recursion Map. 2. Identification of an unexpected, druggable gene similar to BIRC2. 3. Identification of novel dual-targeting checkpoint modifier.",
      "attrs": null,
      "subkind": "numbered",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "51df1b4d-4bd8-46f9-9555-107ded95fb01",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.3,
        "w": 0.25,
        "x": 0.71,
        "y": 0.43
      },
      "kind": "paragraph",
      "text": "Monitor local immune engagement: Show immune-based clearance and associated cytokines. Measure peripheral inflammation: Show reduced inflammatory risk.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9f888f0b-eee2-4741-8ddb-5e247977317f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.2,
        "x": 0.03,
        "y": 0.97
      },
      "kind": "source-note",
      "text": "1 Manguso et al., 2017, Lawson et al., 2020",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "33464f57-ced5-40ea-9494-38a5453ff1c6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.9,
        "x": 0.03,
        "y": 0.09
      },
      "kind": "title",
      "text": "Potential first-in-class NCE with novel MOA to enhance anti-PD-(L)1 response",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ab34aa78-42d6-456b-8bd6-c4bea010edf6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.2,
        "x": 0.03,
        "y": 0.05
      },
      "kind": "title",
      "text": "Pre-clinical: Target α",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8a2a28f0-6209-4646-8f39-81a1b657c774",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "List presentation",
      "slug": "list-presentation",
      "agent": null,
      "layer": "slide",
      "matchId": "29fb90ce-3cf7-4dec-992d-faa5a90625bf",
      "evidence": "list/numbered: 1. Evaluation of 110 sensitization and resistance markers from public pooled CRISPR screens in the Recursion Map. 2. Identification of an unexpected, druggable gene similar to BIRC2. 3. Identification of n",
      "confidence": 0.8
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 120,
      "from": 15,
      "beatId": "136386a5-6141-40a4-88e2-1f9e9bd0026c",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Solution (Provide relief)",
      "beatSlug": "problem-agitate-solution-solution-provide-relief",
      "evidence": "The document presents Recursion's solution, including its technology, approach, and progress in drug discovery.",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Resolution",
      "parentBeatSlug": "resolution"
    }
  ],
  "loops": [
    {
      "to": 120,
      "from": 15,
      "name": "Jobs To Be Done",
      "slug": "53-jobs-to-be-done",
      "bestFor": "Product innovation, market entry, competitive positioning",
      "matchId": "781e998b-dc37-46ea-ab12-3271a3953fda",
      "evidence": "The document presents Recursion's solution, including its technology, approach, and progress in drug discovery.",
      "position": 1,
      "objective": "How can Recursion's technology and approach improve drug discovery outcomes?",
      "structure": "The Customer's Job -> Current Solutions (Hired/Fired) -> Unmet Needs -> Our Solution Fit",
      "confidence": 0.7,
      "description": "Reframe the problem around what the customer is trying to accomplish, not what they're buying"
    }
  ],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}