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  "documentTitle": "Recursion Pharmaceuticals | Investor Day Presentation Deck | 143 slides",
  "authorId": "recursion-pharmaceuticals",
  "authorName": "Recursion Pharmaceuticals",
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  "presentationDate": "2023-01-01 00:00:00",
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  "notes": "Clinical: FAP context. Slide 111.",
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      "text": "Recursion formulation yields exposures comparable to Takeda\nNo food effect\nDose proportional increases in exposure\nSimilar to C20001 study, observed pERK inhibition (i.e. target engagement) at 8 mg and 12 mg doses\nAcceptable safety profile",
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      "text": "Group 1 (n=13): Food effect crossover (REC-4881 4 mg/PBO [fed/fasted]), followed by single dose REC-4881 8 mg/PBO [fed]\nGroup 2 (n=12): Matched single ascending dose (REC-4881 4 mg/PBO; REC-4881 8 mg/PBO; REC-4881 12 mg/PBO)",
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      "text": "REC-4881-101: Single-center, double-blind, placebo-controlled, dose-escalation study in healthy volunteers",
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      "text": "Note: AE, adverse event; MEK, mitogen-activated protein kinase; NHV, normal healthy volunteer; pERK, phosphorylated extracellular signal-regulated kinase; SAE, serious adverse event.",
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      "kind": "title",
      "text": "Further Confidence : Clinical Data Generated by Recursion",
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