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  "documentTitle": "BenevolentAI | Investor Conference Presentation Deck | 29 slides",
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      "text": "BEN-8744: Oral, peripherally-restricted, PDE10 inhibitor under development as a first-in-class treatment for refractory UC",
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      "text": "64% of patients are mild-moderate, 31% of patients are moderate-severe and 5% of patients are severe-fulminant",
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      "text": "Using our Molecular Design expertise we optimally designed a best in class peripherally restricted PDE10 inhibitor: BEN-8744",
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      "text": "Safety - Treatments have many side effects — from steroids to anti-TNF and JAK inhibitors (black box warnings)",
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      "text": "BEN-8744 will target Moderate and Severe UC/IBD patients, meeting the unmet need left by existing therapies including: Patients refractory to anti-TNFs or other biologics; Improved safety and tolerability; Precision Medicine approach",
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      "text": "A chronic, lifelong disease that causes inflammation and ulceration of the inner lining of the colon and rectum",
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      "text": "Affects 0.4% US population, 1.7 million patients in 7MM, forecast $7.8bn market by 2026",
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      "text": "Phosphodiesterase 10 (PDE10) was identified by our TargetID platform as an entirely novel target for the treatment of UC/IBD",
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      "text": "Sources: (1) GlobalData; (2) Evaluate Pharma; (3) Roda et al.; (4) Kobayashi et al.",
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