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  "notes": "POM = Proof of Mechanism; PK = Pharmacokinetics; PD = Pharmacodynamics; DL = Dose Level; KD = Knockdown; DLT = Dose-Limiting Toxicity; SAE = Serious Adverse Event.",
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      "text": "First two dose levels completed\nPK and PD profiles in DL1 and DL2 consistent with preclinical data supporting once every three-week dosing regimen\nUp to 95/100% KD of Ikaros/Aiolos and 40% KD of IRAK4 in blood\nConsistent degradation in blood and tumor\nAt least 72h target degradation observed, a profile that in preclinical species led to robust antitumor activity in MYD88 mutant tumors\nFirst 2 dose levels generally well-tolerated with no DLTs, treatment-related SAEs or neutropenia observed\nDL3 currently enrolling patients\nDL3/4 expected to be clinically active doses",
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