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  "documentTitle": "Kymera | Results Presentation Deck | 63 slides",
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  "notes": "Shows efficacy data (tumor volume) alongside PK/PD mechanism data (degradation over time).",
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      "text": "Single 10 mg/kg dose showed extended tumor exposure and strong degradation of both IRAK4 and IMiD substrates that was maintained for least 72hr in preclinical models. Target PD 80-90% Ikaros KD and 50-70% IRAK4 KD in tumor for ≥72 hrs to achieve robust anti-tumor activity",
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      "text": "In the OCI-LY10 MYD88MT xenograft model, intermittent dosing of KT-413 induced strong antitumor activity, including complete regressions. Superior activity compared to IMiD CC-220 alone",
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      "text": "Complete Tumor Regressions Associated with Robust IRAK4 and Ikaros/Aiolos Degradation for ~72h",
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