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  "documentTitle": "Tonix Pharmaceuticals | Investor Presentation Deck | 29 slides",
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  "presentationDate": "2022-10-01 00:00:00",
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  "notes": "Clinical trial design slide for Tonix Pharmaceuticals.",
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      "text": "TNX-102 SL once-daily at bedtime 5.6 mg (2 x 2.8 mg tablets)*",
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      "text": "General study characteristics: Randomized, double-blind, placebo-controlled study in fibromyalgia; U.S. sites only, expected to enroll approximately 470 patients; One unblinded interim analysis based on 50% of randomized participants",
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      "text": "Primary Endpoint: Daily diary pain severity score change from baseline to Week 14 (TNX-102 SL vs. placebo); Weekly averages of the daily numerical rating scale scores; Analyzed by mixed model repeated measures with multiple imputation (MMRM with MI)",
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      "text": "*Two week run in at 2.8 mg dose at bedtime, followed by 12 weeks at 5.6 mg dose",
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