{
  "docId": "019de073-dba4-758b-bcbe-08ad83e87d71",
  "docSlug": "afc13b14322819221680611098a4aee7",
  "documentTitle": "Third Harmonic Bio | Investor Presentation Deck | 20 slides",
  "authorId": "third-harmonic-bio",
  "authorName": "Third Harmonic Bio",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-10-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 9,
  "pageCount": 20,
  "prevPage": 8,
  "nextPage": 10,
  "slideType": "appendix_methodology",
  "function": "present_framework",
  "density": "dense",
  "nDataPoints": 14,
  "notes": "The slide uses a staircase diagram to represent dose escalation and a crossover design for the food effect study.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de073-dba4-758b-bcbe-08ad83e87d71/9",
  "deckHref": "/decks/019de073-dba4-758b-bcbe-08ad83e87d71",
  "deckJsonHref": "/decks/019de073-dba4-758b-bcbe-08ad83e87d71.json",
  "deckAnchorHref": "/decks/019de073-dba4-758b-bcbe-08ad83e87d71#slide-9",
  "components": [
    {
      "bbox": {
        "h": 0.45,
        "w": 0.94,
        "x": 0.03,
        "y": 0.28
      },
      "kind": "diagram",
      "text": "SAD staircase and MAD staircase with central food effect crossover",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4b740ad0-1362-4375-9684-510594270201",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.75,
        "x": 0.2,
        "y": 0.73
      },
      "kind": "list",
      "text": "Assess safety and tolerability; Characterize pharmacokinetics, including in presence/absence of food to inform further clinical and drug product formulation development; Measure pharmacodynamic effect by serum tryptase",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b0152cb1-01f9-4ace-bb73-055ec86d3cff",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.6,
        "x": 0.03,
        "y": 0.06
      },
      "kind": "title",
      "text": "THB001: Phase 1 SAD/MAD/Food Effect in Healthy Volunteers",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "839e3b9c-dd56-402b-891f-d30981c1357c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.15,
        "x": 0.03,
        "y": 0.78
      },
      "kind": "title",
      "text": "Key Objectives",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "de521fe7-ef7e-4d42-854e-fa0cc83ee86b",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.2,
        "x": 0.4,
        "y": 0.22
      },
      "kind": "title",
      "text": "Phase 1a Trial Design",
      "attrs": null,
      "subkind": "subtitle",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3922b9c2-fc2f-46a4-a704-fa2efb91763f",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "clinical-trial-design",
      "slug": null,
      "matchId": "e0ed0469-09d6-4948-9371-79fa3d9de16c",
      "evidence": "Standard representation of SAD/MAD study cohorts",
      "confidence": 0.9
    }
  ],
  "arcBeats": [
    {
      "to": 14,
      "from": 7,
      "beatId": "45cf8a86-de32-4d74-8704-aa8f3cd45c24",
      "arcName": "The Sequoia Pitch",
      "arcSlug": "sequoia-pitch",
      "beatName": "Solution",
      "beatSlug": "sequoia-pitch-solution",
      "evidence": "Slides 7-14 provide data and results on THB001, including its ability to inhibit mast cell activity",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Turn",
      "parentBeatSlug": "turn"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}