{
  "docId": "019de073-d2da-762c-9a26-b97a59cfec30",
  "docSlug": "f7af69768ee002be4e2317aa5e807561",
  "documentTitle": "Revelation Biosciences | Investor Presentation Deck | 18 slides",
  "authorId": "revelation-biosciences",
  "authorName": "Revelation Biosciences",
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  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-10-01 00:00:00",
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  "pageNumber": 7,
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  "notes": "The slide presents three dot plots comparing Vehicle, MPLA, PHAD, 3D PHAD, and 3D 6-Acyl PHAD treatments.",
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      "kind": "chart",
      "text": "Total Neutrophils, Total Monocytes, P. aeruginosa Clearance",
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      "kind": "paragraph",
      "text": "Pre-treatment with MPLA or PHAD(s) demonstrated TLR4-mediated increased leukocyte recruitment and reduced pro-inflammatory cytokines (IL-6, TNF-α) in peritoneal cavity",
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      "kind": "paragraph",
      "text": "Pre-treatment with MPLA and PHAD(s) demonstrated TLR4-mediated pathogen clearance:",
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      "kind": "source-note",
      "text": "Hernandez et. al_ Phosphorylated Hexa-Acyl Disaccharides Augment Host Resistance Against Common Nosocomial Pathogens. DOI: 10.1097/CCM.0000000000003967",
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      "text": "Study Design: Mice were pre-treated (24 and 48 hours) with vehicle, MPLA (20ug), or PHADs (20ug) prior to infection with P. aeruginosa. All given IP. Cell counts assessed from peritoneal lavage 6 hours post infection",
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      "kind": "title",
      "text": "Pretreatment with PHADs Impart Protection from Gram Negative Bacterial Infection",
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      "arcName": "The Sequoia Pitch",
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      "evidence": "Slides 4-15 describe various solutions, including PHAD, REVTx-100, REVTx-200, and REVDx-501.",
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      "name": "Zoom In",
      "slug": "06-zoom-in",
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      "evidence": "Slides 7-8 provide traction data on PHADs' protective effects.",
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      "objective": "What are the benefits of PHADs in protecting against bacterial infections?",
      "structure": "The Big Picture -> Key Area of Focus -> Specific Detail -> Implication",
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      "evidence": "Slides 4-15 describe PHAD and its applications.",
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      "objective": "Why is PHAD a well-defined TLR4 agonist with multiple potential applications?",
      "structure": "The Why (Belief) -> The How (Process) -> The What (Result)",
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