{
  "docId": "019de073-ce1e-74cc-9870-b1827d8467a5",
  "docSlug": "ce894072ac0bdbdb4be0c6e520599e56",
  "documentTitle": "Nuvalent | Investor Presentation Deck | 31 slides",
  "authorId": "nuvalent",
  "authorName": "Nuvalent",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-10-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 25,
  "pageCount": 31,
  "prevPage": 24,
  "nextPage": 26,
  "slideType": "key_messages",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 1,
  "notes": null,
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de073-ce1e-74cc-9870-b1827d8467a5/25",
  "deckHref": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5",
  "deckJsonHref": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5.json",
  "deckAnchorHref": "/decks/019de073-ce1e-74cc-9870-b1827d8467a5#slide-25",
  "components": [
    {
      "bbox": {
        "h": 0.55,
        "w": 0.058,
        "x": 0.512,
        "y": 0.265
      },
      "kind": "image",
      "text": null,
      "attrs": null,
      "subkind": "icon-grid",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3febd995-8ebc-41c8-be54-f076a2269f02",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.04,
        "w": 0.28,
        "x": 0.586,
        "y": 0.75
      },
      "kind": "list",
      "text": "TRK sparing to minimize CNS adverse events",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "876760d9-bbaa-4969-b13c-939f6941d935",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.35,
        "x": 0.586,
        "y": 0.575
      },
      "kind": "list",
      "text": "Brain penetrant ~30 – 40% of patients with ALK-positive NSCLC present with brain metastases",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c2f66f63-7b5f-4f05-a5be-76a3882a2d17",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.37,
        "x": 0.586,
        "y": 0.418
      },
      "kind": "list",
      "text": "Active against treatment-emergent ALK G1202R single and compound resistance mutations e.g., G1202R/L1196M, G1202R/G1269A, G1202R/L1198F",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c807f33a-6cc4-4ced-8614-c4ae5cb127d1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.28,
        "x": 0.586,
        "y": 0.29
      },
      "kind": "list",
      "text": "Active against wild-type ALK fusions",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f9e7afd0-3946-4c5d-a3c6-90a4f3d67d87",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.332,
        "x": 0.106,
        "y": 0.318
      },
      "kind": "title",
      "text": "NVL-655 for ALK-Positive Advanced NSCLC and Other Solid Tumors",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1b26e2d4-ec73-4246-afd7-3abe1dbcb3a5",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.252,
        "x": 0.512,
        "y": 0.188
      },
      "kind": "title",
      "text": "TARGET PRODUCT PROFILE:",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9d41b385-752e-4d2a-a304-31f925d5f255",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "List presentation",
      "slug": "list-presentation",
      "agent": null,
      "layer": "slide",
      "matchId": "b1c06be6-3b8c-44f8-9542-40bc8229e8bb",
      "evidence": "list/bullet: Active against treatment-emergent ALK G1202R single and compound resistance mutations e.g., G1202R/L1196M, G1202R/G1269A, G1202R/L1198F",
      "confidence": 0.8
    }
  ],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}