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  "notes": "Uses a biological analogy (brake pedal) to explain gene function.",
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      "text": "Tumor suppressor genes such as TUSC2 are deleted early during cancer development\n80% of all non-small cell lung cancers express decreased amounts of TUSC2 tumor suppressor protein\nLoss or reduction of TUSC2 expression is associated with significantly worse overall survival\nLed to the hypothesis that reintroduction of tumor suppressor genes may be a new method of treating cancer",
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      "text": "Ji L, Nishizaki M, Gao B, et al. Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. Cancer Res. 2002;62(9):2715-2720.",
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