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  "authorName": "Daré Bioscience",
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  "notes": "The slide presents clinical trial data comparing baseline to month 3 outcomes and systemic absorption levels.",
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      "text": "This exploratory study in four postmenopausal women diagnosed with VVA demonstrated that a self-administered vaginal suppository containing tamoxifen (20mg) dosed daily for one week and twice weekly for three months was effective in reducing vaginal pH and vaginal dryness.",
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      "text": "In addition, systemic absorption of tamoxifen was not significant: After 8 weeks of study treatment with vaginal tamoxifen, median plasma concentration of tamoxifen was 5.8 ng/ml... In comparison, after 3 months of administration of 20mg, once-daily oral tamoxifen citrate (Nolvadex), the average steady state plasma concentration of tamoxifen is 122 ng/ml",
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      "text": "1. Clin. Exp. Obstet. Gynecol. - ISSN: 0390-6663 XLVI, n. 2, 2019; 2. https://www.medicalnewstoday.com/articles/322537.php; 3. US Food and Drug Administration: “Drug Approval Package: Nolvadex (Tamoxifen Citrate) NDA# 21-109.2002”.",
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      "text": "Vaginal Tamoxifen, Enrollment (Baseline), On Treatment (Month 3), Paired Difference (Baseline vs. Month 3), Median Vaginal pH, 7.1, 5.0, -2.0 median, Vaginal Dryness, 8.0, 3.0, -5.5 median",
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      "kind": "title",
      "text": "DARE-VVA1 - Proof of Concept",
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