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  "documentTitle": "BrainStorm Cell Therapeutics | Investor Presentation Deck | 15 slides",
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  "presentationDate": "2022-10-01 00:00:00",
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  "notes": "The slide outlines the primary endpoint (Clinical Response) and a secondary/supporting metric (piecewise slope) for ALS clinical trials.",
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      "text": "Clinical outcome based on change between pre-treatment and post-treatment: Clinical Response (primary endpoint)a\nSee Cudkowicz, et al. Musc Nerve, Jan 2022 for results",
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      "text": "Clinical outcome based on a post treatment change (rate of decline): piecewise slopeb",
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      "text": "Two different clinical measures based on ALSFRS-R specified in the biomarker SAP:",
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      "text": "a ≥1.25 points/month improvement in post-treatment vs. pre-treatment slope in ALSFRS-R score through week 28\nb Powerful model which jointly borrows information available from the pre-treatment period to better characterize the slope post-treatment",
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      "text": "Clinical Outcomes Considered as Measure of Efficacy",
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