{
  "docId": "019de073-aaaa-768c-937f-f768840b87a6",
  "docSlug": "9b8664e841ca83938179aa04bf759b1d",
  "documentTitle": "BrainStorm Cell Therapeutics | Investor Presentation Deck | 15 slides",
  "authorId": "brainstorm-cell-therapeutics",
  "authorName": "Brainstorm Cell Therapeutics",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-10-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 14,
  "pageCount": 15,
  "prevPage": 13,
  "nextPage": 15,
  "slideType": "key_takeaways",
  "function": "summarize",
  "density": "overcrowded",
  "nDataPoints": 0,
  "notes": null,
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de073-aaaa-768c-937f-f768840b87a6/14",
  "deckHref": "/decks/019de073-aaaa-768c-937f-f768840b87a6",
  "deckJsonHref": "/decks/019de073-aaaa-768c-937f-f768840b87a6.json",
  "deckAnchorHref": "/decks/019de073-aaaa-768c-937f-f768840b87a6#slide-14",
  "components": [
    {
      "bbox": {
        "h": 0.03,
        "w": 0.6,
        "x": 0.295,
        "y": 0.628
      },
      "kind": "list",
      "text": "The Relationship Between Biomarkers and Clinical Outcomes reveal biomarkers across 3 pathways are important to predicting the clinical response observed.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "09877369-99d8-4cd6-8cbe-83d4b454bed4",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.65,
        "x": 0.273,
        "y": 0.458
      },
      "kind": "list",
      "text": "Statistical modeling identifies biomarkers that have the potential to predict a clinical response with NurOwn, with two different clinical endpoints",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "55ae88de-f191-4a84-86a1-530c589a1e80",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.65,
        "x": 0.273,
        "y": 0.338
      },
      "kind": "list",
      "text": "The same biomarker responses, including patterns by treatment, are observed across biomarker pathways in participants with less advanced ALS, and advanced ALS",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8568ef81-507a-4393-a035-b76b462fe1a1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.6,
        "x": 0.295,
        "y": 0.543
      },
      "kind": "list",
      "text": "Markers of neuroinflammation, neurodegeneration and neuroprotection were all selected in the final model.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "abf2639a-96fd-4c92-b5db-75f7da6a39b1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.06,
        "w": 0.65,
        "x": 0.273,
        "y": 0.218
      },
      "kind": "list",
      "text": "Treatment with NurOwn elevates markers of neuroprotection, and lowers markers of neuroinflammation and neurodegeneration over time compared to placebo",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "af5cb483-ac9b-4c0a-947b-47fe4b23d4c5",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.65,
        "x": 0.273,
        "y": 0.783
      },
      "kind": "list",
      "text": "Novel therapies that simultaneously target multiple pathways may offer great potential",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ffe2b5df-f183-4dcb-8e2c-10c49af0c03e",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.023,
        "w": 0.781,
        "x": 0.027,
        "y": 0.117
      },
      "kind": "title",
      "text": "Changes in biomarkers following NurOwn treatment are statistically linked to clinical outcomes from the trial",
      "attrs": null,
      "subkind": "action-title",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "36e54f5e-886e-4c89-8e8d-0c17e4f551b1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.031,
        "w": 0.085,
        "x": 0.027,
        "y": 0.043
      },
      "kind": "title",
      "text": "Summary",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8a030a64-092a-4568-9b49-390e0695b295",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 14,
      "from": 6,
      "beatId": "1e09c995-6c2c-4ea3-94d4-8282e303405f",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Solution",
      "beatSlug": "problem-agitate-solution-solution-provide-relief",
      "evidence": "Slides 6-14 present NurOwn as a potential solution",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Resolution",
      "parentBeatSlug": "resolution"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}