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      "text": "Chemical structures of Ketamine, S-ketamine, and R-ketamine",
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      "text": "R-ketamine shows an improved therapeutic index in preclinical studies and in a pilot, third-party clinical trial; R- and S-ketamine may demonstrate neuroplastic effects through different mechanisms",
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      "text": "1. Wei et al., “A historical review of antidepressant effects of ketamine and its enantiomers” (2020); 2. Chang et al., “Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine Pharmacology Biochemistry and Behavior” (2019)",
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