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  "documentTitle": "Aeglea BioTherapeutics | Investor Day Presentation Deck | 28 slides",
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  "notes": "The diagram illustrates the metabolic pathway and the specific block at the Cystathionine beta-synthase step.",
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      "text": "Metabolic pathway diagram showing conversion of Dietary protein to Methionine, Homocysteine, Cystathionine, and Cysteine, with a block at Cystathionine beta-synthase.",
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      "text": "Defective CBS enzyme\nPathophysiologic accumulation of Hcy\nInterference with normal cellular processes",
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      "text": "CBS, cystathionine beta-synthase; HCU, homocystinuria; Hcy, homocysteine. 1. Morris AA, et al. J Inherit Metab Dis. 2017;40:49–74; 2. Sacharow SJ, et al. Homocystinuria caused by cystathionine beta-synthase deficiency. 2017. In: Adam MP, et al. GeneReviews® [Internet]. Seattle (WA); 1993–2021.",
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