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      "text": "All possible triple mutants of 19 amino acids in 20 positions (CDR2 & CDR3)",
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      "text": "Combinatorial mutagenesis of up to 3 mutations over ten amino acids each in CDRH2 and CDRH3; Sampled less than 1% of the sequence space; Measured binding affinity of nearly 50,000 sequence variants; Predictive performance of triple-mutant dataset is comparable to the double-mutant library (Pearson R>0.9)",
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      "text": "Bachas, S., Rakocevic, G. et al. Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness (2022) pre-print in bioRxiv.",
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