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  "notes": "The chart shows density vs -log10Kd, comparing design vs validation vs measured trastuzumab.",
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      "text": "74% of variants were tighter binders than the parental antibody - trained with the SPR-generated trast-2 dataset",
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      "text": "1. tasked model trained with trast-2 dataset with designing sequences spanning 2-orders of magnitude of equilibrium dissociation constants\n2. Found an agreement between predictions and validations\n3. Assessed the model's ability to design variants with tighter binding than trastuzumab\n4. Validated 50 sequences by SPR",
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      "text": "Bachas, S., Rakocevic, G. et al. Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness (2022) pre-print in bioRxiv.",
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