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  "documentTitle": "Third Harmonic Bio | IPO Presentation Deck | 24 slides",
  "authorId": "third-harmonic-bio",
  "authorName": "Third Harmonic Bio",
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  "sourceTypeSlug": "investment_bank",
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  "presentationDate": "2022-09-01 00:00:00",
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  "density": "dense",
  "nDataPoints": 4,
  "notes": "Includes medical imagery of lungs and mast cells.",
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      "text": "Lungs illustration",
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      "text": "Mast cell illustration",
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      "text": "Prevalence: ~5-10% of all asthma patients; estimated 750K – 1 million patients in US; adult population ~60% female, mean age ~50 years\nDefinition: disease not sufficiently controlled with standard nonbiologic treatments; reduced lung function, higher incidence of exacerbations\nMast cells shown to play a central role: in both regulation of both lower airway inflammation and airway hyperresponsiveness\nCurrent oral treatment options are limited: multiple approved biologics, but no new oral therapy approved for asthma since anti-leukotrienes in late 1990s\nNew oral treatment options with the potential to treat across all severe asthma endotypes are needed",
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      "kind": "title",
      "text": "Limited oral treatment options for patients beyond corticosteroids and anti-leukotrienes",
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      "kind": "title",
      "text": "Severe Asthma Disease Overview",
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      "beatName": "Market Size",
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      "evidence": "The deck presents an overview of the market size on pages 20 and 21, discussing chronic urticaria and severe asthma.",
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      "name": "Cost Of Inaction",
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      "bestFor": "Urgent budget requests, compliance, risk mitigation",
      "matchId": "1637e937-fd9b-4682-939c-d684884ac925",
      "evidence": "The deck presents the limitations of current treatments and the potential benefits of THB001.",
      "position": 0,
      "objective": "What is the cost of not treating mast cell-mediated diseases effectively?",
      "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point",
      "confidence": 0.7,
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    },
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      "objective": "Can THB001 achieve quick wins and make a big impact in the treatment of mast cell-mediated diseases?",
      "structure": "The Full List -> Quick Wins (Low effort, High impact) -> Big Bets (High effort, High impact) -> Sequenced Roadmap",
      "confidence": 0.6,
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