{
  "docId": "019de073-8079-71bb-b12b-cbebf2163a3a",
  "docSlug": "9b4d00e952721e20753466aee3e72db7",
  "documentTitle": "BenevolentAI | Investor Day Presentation Deck | 74 slides",
  "authorId": "benevolentai",
  "authorName": "BenevolentAI",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-09-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 58,
  "pageCount": 74,
  "prevPage": 57,
  "nextPage": 59,
  "slideType": "propose_solution",
  "function": "present_solution",
  "density": "overcrowded",
  "nDataPoints": 8,
  "notes": "The slide uses a process diagram to explain the experimental setup and bar charts to show the efficacy of the compound in reducing IL-6 and IL-8 levels.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de073-8079-71bb-b12b-cbebf2163a3a/58",
  "deckHref": "/decks/019de073-8079-71bb-b12b-cbebf2163a3a",
  "deckJsonHref": "/decks/019de073-8079-71bb-b12b-cbebf2163a3a.json",
  "deckAnchorHref": "/decks/019de073-8079-71bb-b12b-cbebf2163a3a#slide-58",
  "components": [
    {
      "bbox": {
        "h": 0.15,
        "w": 0.4,
        "x": 0.05,
        "y": 0.75
      },
      "kind": "callout",
      "text": "Validated as a target with a novel mechanism of action for ulcerative colitis",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "60a3eb6c-d98c-4e4c-9299-3ae5541f59c9",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.4,
        "w": 0.4,
        "x": 0.55,
        "y": 0.5
      },
      "kind": "chart",
      "text": "IL-6 and IL-8 levels across DMSO, Prednisolone, Tofacitinib, and BEN-3218",
      "attrs": null,
      "subkind": "bar-vertical",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2a940859-aabb-4c59-983b-361b4bdc2091",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.3,
        "w": 0.4,
        "x": 0.55,
        "y": 0.15
      },
      "kind": "diagram",
      "text": "Endoscopic Biopsy from UC patients -> Colonic mucosa organ culture and compound treatment -> Inflammatory cytokine measurement",
      "attrs": null,
      "subkind": "process",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "eadd0465-b4da-45e2-bb9a-e822ce3bb3e8",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.4,
        "x": 0.05,
        "y": 0.45
      },
      "kind": "list",
      "text": "Tissue samples treated with: Target-selective tool compound (BEN-3218); Positive controls – prednisolone and tofacitinib",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "13d95f8b-f023-48f2-8d62-77c20c1e6927",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.4,
        "x": 0.05,
        "y": 0.25
      },
      "kind": "list",
      "text": "Inflamed colonic mucosa biopsies from UC patients: Disease phenotype retained with high basal cytokine release; Readouts: IL6 and IL8 - key mediators of UC pathology",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "84b236a3-aa33-47a6-8ed6-cf2bffa7b411",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.4,
        "x": 0.05,
        "y": 0.6
      },
      "kind": "paragraph",
      "text": "Selective target inhibition showed comparable reduction of IL-6 and IL-8 to the positive controls",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "81b171a4-63ed-4919-bc56-be861975c611",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.1,
        "w": 0.9,
        "x": 0.05,
        "y": 0.05
      },
      "kind": "title",
      "text": "Target validation in colon tissue from ulcerative colitis patients",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "4076f754-e88d-4ce8-a8c0-efe47ccdaefd",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "Monroe's Motivated Sequence",
      "slug": "monroes-motivated-sequence",
      "agent": "Storyteller",
      "layer": "slide",
      "matchId": "c3848d8e-4e62-4fe5-896f-259f5b9e7d81",
      "evidence": "list/bullet: Inflamed colonic mucosa biopsies from UC patients: Disease phenotype retained with high basal cytokine release; Readouts: IL6 and IL8 - key mediators of UC pathology",
      "confidence": 0.6
    }
  ],
  "frameworks": [],
  "arcBeats": [
    {
      "to": 74,
      "from": 8,
      "beatId": "e075ee7a-56af-49ed-87dd-38efd7ca183a",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Solution (Provide relief)",
      "beatSlug": "problem-agitate-solution-solution-provide-relief",
      "evidence": "The Benevolent Platform™: a versatile, scalable and proven AI-enabled R&D engine",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": "Resolution",
      "parentBeatSlug": "resolution"
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}