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  "notes": "Includes a biological mechanism diagram showing NGF, BDNF, and NTF-3 binding to TrkA, TrkB, and TrkC receptors.",
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      "text": "Diagram of Trk receptors (TrkA, TrkB, TrkC) and their ligands (NGF, BDNF, NTF-3) interacting with cell membrane components.",
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      "text": "BEN-2293 is a PanTrk inhibitor targeting TrkA, B and C receptors. BEN-2293 is expected to treat atopic dermatitis by inhibiting itch signaling and blocking nerve sensitization. BEN-2293 will target Mild, Moderate and Severe Atopic Dermatitis patients.",
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      "text": "Key: Tropomyosin-related kinase (Trk) receptor tyrosine kinase family, namely TrkA, TrkB, and TrkC; Nerve Growth Factor (NGF); Brain Derived Neurotrophic Factor (BDNF); Neurotrophin-3 (NTF-3)/NT3. Image source: Amatu et al. ESMO Open 2016",
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      "text": "Neurotrophins bind to high affinity receptors (TrkA, B and C), directly activating both inflammation and itch signalling which propagates a cycle of itching and scratching.",
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      "kind": "title",
      "text": "BEN-2293 - A potent PanTrk antagonist developed to relieve inflammation and provide rapid itch resolution Atopic Dermatitis",
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