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  "documentTitle": "Axcella Health | Results Presentation Deck | 62 slides",
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  "presentationDate": "2022-09-01 00:00:00",
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  "notes": "The slide presents longitudinal data from the REGENERATE trial, specifically focusing on FIB-4 scores as a non-invasive test (NIT) for fibrosis.",
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      "text": "FIB-4 score change over time for Placebo, OCA 10mg, and OCA 25mg",
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      "text": "Patients with >1-stage fibrosis improvement had the greatest improvement in NITs, while patients with ≥1-stage fibrosis worsening typically showed no NIT improvement. AUROC values for each of these were suggestive of only weak association. NIT improvements observed in REGENERATE are associated with fibrosis improvement at Month 18, individual NIT changes are not likely to be effective univariate clinical predictors of fibrosis improvement by Month 18.",
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      "text": "Rinella ME. Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study. J Hepatol. 2022 Mar;76(3):536-548",
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      "text": "EVIDENCE FROM REGENERATE TRIAL 18-MONTH INTERIM ANALYSIS – OBETICHOLIC ACID",
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