{
  "docId": "019de073-7e4e-7689-a01c-e0840dac2b61",
  "docSlug": "97e34d6c4db7d9454440fee3efd43545",
  "documentTitle": "Axcella Health | Results Presentation Deck | 62 slides",
  "authorId": "axcella-health",
  "authorName": "Axcella Therapeutics",
  "documentKindSlug": "conference-presentation",
  "documentKindLabel": "Conference presentation",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-09-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7761332,
  "pageNumber": 4,
  "pageCount": 62,
  "prevPage": 3,
  "nextPage": 5,
  "slideType": "propose_solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 0,
  "notes": "The diagram illustrates a hub-and-spoke model showing systemic interaction of EMMs across various organs.",
  "elementsJson": null,
  "metadataConfidence": 0.95,
  "imagePath": null,
  "slideHref": "/slides/019de073-7e4e-7689-a01c-e0840dac2b61/4",
  "deckHref": "/decks/019de073-7e4e-7689-a01c-e0840dac2b61",
  "deckJsonHref": "/decks/019de073-7e4e-7689-a01c-e0840dac2b61.json",
  "deckAnchorHref": "/decks/019de073-7e4e-7689-a01c-e0840dac2b61#slide-4",
  "components": [
    {
      "bbox": {
        "h": 0.1,
        "w": 0.55,
        "x": 0.03,
        "y": 0.78
      },
      "kind": "callout",
      "text": "Axcella's clinical data demonstrate the potential to harness the power of EMMs to tackle complex chronic conditions",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8ec5b0c0-454c-4020-9fea-c7b1dc04b0ba",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.7,
        "w": 0.38,
        "x": 0.58,
        "y": 0.18
      },
      "kind": "image",
      "text": "Circular diagram showing EMMs interacting with various body systems (Brain, Immune, Muscle, Kidneys, Circulatory, GI, Liver, Adipose)",
      "attrs": null,
      "subkind": "illustration",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "15a4a4c1-3f5a-4f06-ad73-3fa5fb2d52b1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.55,
        "w": 0.45,
        "x": 0.03,
        "y": 0.21
      },
      "kind": "list",
      "text": "Complex conditions are driven by dysregulation in multiple biological pathways, limiting the effect of single-targeted therapies. Amino acid-based therapeutics can be safely used to: Regulate key signaling pathways, Restore mitochondrial function, Shift substrate/redox balance to restore homeostasis. Potential therapeutic benefits include: Enhancing muscle function, Improving neurocognition, Correcting metabolism, Rebalancing IEMs, Decreasing inflammation, Reducing fibrosis",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "9f4215ec-f219-40bf-a048-d8616033fb08",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.2,
        "x": 0.03,
        "y": 0.91
      },
      "kind": "source-note",
      "text": "IEM = Inborn Errors of Metabolism",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5e82ce16-85e8-4272-a6e6-0aa485d3670c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.45,
        "x": 0.03,
        "y": 0.06
      },
      "kind": "title",
      "text": "Multi-Targeted Therapeutics to Restore Homeostasis",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "74ff6b0b-2a4e-4ba0-9f2f-1a9f07aedcf3",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.04,
        "w": 0.55,
        "x": 0.03,
        "y": 0.12
      },
      "kind": "title",
      "text": "Leveraging Endogenous Metabolic Modulator (EMM) compositions to treat complex medical conditions",
      "attrs": null,
      "subkind": "subtitle",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1a5d149c-f232-4713-a6d9-9e6c915fee6f",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [
    {
      "name": "AIDA Model",
      "slug": "aida-model",
      "agent": "Storyteller",
      "layer": "slide",
      "matchId": "b8a9e129-34d3-44c7-a12a-75cfbae5013d",
      "evidence": "callout/primary: Axcella's clinical data demonstrate the potential to harness the power of EMMs to tackle complex chronic conditions",
      "confidence": 0.7
    }
  ],
  "frameworks": [
    {
      "name": "hub-spoke",
      "slug": null,
      "matchId": "f069d7de-46fd-4dd9-aba0-c88d4ffa0372",
      "evidence": "Circular diagram showing central EMMs connecting to various organ systems",
      "confidence": 0.8
    }
  ],
  "arcBeats": [
    {
      "to": 4,
      "from": 4,
      "beatId": "bf47ac09-c6e9-4a67-96b8-4dd80291c456",
      "arcName": "Problem-Agitate-Solution",
      "arcSlug": "problem-agitate-solution",
      "beatName": "Propose Solution",
      "beatSlug": null,
      "evidence": "Multi-targeted therapeutics to restore homeostasis",
      "position": 2,
      "confidence": 0.8,
      "parentBeatName": null,
      "parentBeatSlug": null
    }
  ],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}