{
  "docId": "019de073-3800-772b-871e-98f0ed79adc7",
  "docSlug": "3d30d84bb133b7b226440021781a4f91",
  "documentTitle": "23andMe | Investor Presentation Deck | 58 slides",
  "authorId": "23andme",
  "authorName": "23andMe",
  "documentKindSlug": "pitchdeck",
  "documentKindLabel": "Pitch deck",
  "sourceTypeSlug": "investor_relations",
  "sourceTypeLabel": "Investor relations",
  "presentationDate": "2022-08-01 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.7777778,
  "pageNumber": 41,
  "pageCount": 58,
  "prevPage": 40,
  "nextPage": 42,
  "slideType": "solution",
  "function": "present_solution",
  "density": "dense",
  "nDataPoints": 1,
  "notes": "The slide uses a before-and-after diagram to illustrate the mechanism of action.",
  "elementsJson": null,
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019de073-3800-772b-871e-98f0ed79adc7/41",
  "deckHref": "/decks/019de073-3800-772b-871e-98f0ed79adc7",
  "deckJsonHref": "/decks/019de073-3800-772b-871e-98f0ed79adc7.json",
  "deckAnchorHref": "/decks/019de073-3800-772b-871e-98f0ed79adc7#slide-41",
  "components": [
    {
      "bbox": {
        "h": 0.7,
        "w": 0.35,
        "x": 0.6,
        "y": 0.2
      },
      "kind": "image",
      "text": "23ME'610 Activates T-cell Function by Blocking the CD200R1 Checkpoint",
      "attrs": null,
      "subkind": "infographic",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7819026e-93ac-48b4-b2ea-4bb653e73ecf",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.5,
        "x": 0.03,
        "y": 0.65
      },
      "kind": "list",
      "text": "The restoration of T-cell activity by 23ME '610 was demonstrated using in vitro models of the tumor microenvironment. No adverse effects of blocking CD200R1 have been observed in nonclinical toxicology studies.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "7f202602-85d6-476e-a1ab-b1d3ac459caf",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.4,
        "w": 0.5,
        "x": 0.03,
        "y": 0.25
      },
      "kind": "list",
      "text": "23ME '610 is a fully humanized, effectorless, IgG1 antibody against human CD200R1. 23ME '610 binds CD200R1 with high affinity (KD < 0.1 nM). 23ME '610 blocks CD200 ligand binding to CD200R1, resulting in inhibition of immunosuppressive signaling.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ff376fd9-6c6a-4521-8709-59c37f412b90",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.3,
        "x": 0.03,
        "y": 0.92
      },
      "kind": "source-note",
      "text": "*CD200-expressing cell types include tumor, stroma and endothelial. IFN, interferon; IL, interleukin",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d41ca2c3-0c0b-4ad7-a4db-7b0a208ecf51",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.94,
        "x": 0.03,
        "y": 0.05
      },
      "kind": "title",
      "text": "23ME-00610 (23ME'610) Binds with High Affinity to CD200R1 and Inhibits Immunosuppressive Signaling",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8309eb3c-6ac1-467e-a977-846eac06d3de",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "before-after-framing",
      "slug": null,
      "matchId": "9baf56d8-c76a-4d31-a06b-fccc742af83e",
      "evidence": "The diagram shows the state of T-cell activity before and after the introduction of 23ME-00610.",
      "confidence": 0.9
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}