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      "text": "Non-covalent potency and selectivity: Both potency and selectivity are critically important. Early entrants increased potency and selectivity by covalent bonding. This dramatically increased off target toxicity, leading to discontinuation.",
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      "text": "Short therapeutic window: Ideal therapeutic coverage would be 6-8 hours at IC80. Longer periods will lead to increasing systemic toxicity.",
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      "text": "Bioavailable: CDK7 inhibition will lead to toxicity if it remains at any site other than the tumour. Absorption variability will cause either supra-doses or sub-therapeutic dosing.",
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