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  "notes": "The slide uses a structural biology diagram to explain the modularity of endolysins.",
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      "text": "Engineered endolysins can combine modules of multiple classes. High sequence diversity and option space, even within one class",
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      "text": "Alphafold homology model of PM-477",
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      "text": "EADs hydrolyze peptidoglycan. Different classes of EAD cleave 5 different chemical bonds in peptidoglycan. There are 28++ classes of EADs with low sequence similarity. Endolysins can have ≥1 EADs.",
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      "text": "CBDs bind specific features on bacterial cell wall. CBDs mediate genus or species specificity (but EADs also contribute to specificity). 15+ different classes of CBDs known.",
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      "text": "To be active on Gram negative bacteria (outer-cell membrane), many but not all endolysins require outer-membrane penetrating peptides.",
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      "text": "CBD, Cell-wall binding domain; EAD, enzymatically active domain. 1 Oliveira H, et al. J Virol 2013; 87:4558–4570; 2 Vázquez R, et al. J Virol 2021; 95:e0032121; 3 Gutiérrez D & Briers Y. Curr Opin Biotechnol 2021; 68:15–22.",
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