{ "docId": "019de072-f015-70b3-a108-700a038da3d5", "docSlug": "ab0daada6947ab44927f267f74789e9c", "documentTitle": "Bionomics | Investor Presentation Deck | 16 slides", "authorId": "bionomics", "authorName": "Bionomics", "documentKindSlug": "pitchdeck", "documentKindLabel": "Pitch deck", "sourceTypeSlug": "investor_relations", "sourceTypeLabel": "Investor relations", "presentationDate": "2022-06-01 00:00:00", "orientation": "landscape", "aspectRatio": 1.7777778, "pageNumber": 9, "pageCount": 16, "prevPage": 8, "nextPage": 10, "slideType": "problem_statement", "function": "frame_problem", "density": "overcrowded", "nDataPoints": 1, "notes": "The slide uses a split-layout: left side lists clinical symptoms/causes, right side details functional impact on life domains.", "elementsJson": null, "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019de072-f015-70b3-a108-700a038da3d5/9", "deckHref": "/decks/019de072-f015-70b3-a108-700a038da3d5", "deckJsonHref": "/decks/019de072-f015-70b3-a108-700a038da3d5.json", "deckAnchorHref": "/decks/019de072-f015-70b3-a108-700a038da3d5#slide-9", "components": [ { "bbox": { "h": 0.35, "w": 0.45, "x": 0.04, "y": 0.24 }, "kind": "list", "text": "A debilitating disorder that leads to social, occupational and interpersonal dysfunction\nPTSD involves flashbacks, intrusive thoughts and nightmares\nPTSD causes changes in cognition, mood, arousal and reactivity\nPTSD results from exposure to actual or threatened death, serious injury or sexual violence", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "3c08c25d-72ec-4857-88e5-910c474bcc73", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.08, "w": 0.45, "x": 0.04, "y": 0.73 }, "kind": "list", "text": "Only 20-30% of PTSD patients achieve clinical remission on SoC SSRI therapy", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "6051e7d9-7367-4dfa-bbbd-71c5e3c342af", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.6, "w": 0.45, "x": 0.51, "y": 0.0016 }, "kind": "paragraph", "text": "Work: Patients may orient their careers around a narrow set of potential occupations and may struggle with job performance\nRelationships: PTSD can impair trust, closeness, and communication, leading to difficulty maintaining family and romantic relationships.\nLifestyle: PTSD-associated poor nutrition, reduced physical activity, and increased obesity and smoking, increase risk of cardiovascular and other diseases\nQuality of Life: PTSD patients avoid people, places, or environments which may trigger trauma, making daily living difficult", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "ea301628-ab31-49b4-aa22-d51674fc3cad", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.1, "w": 0.75, "x": 0.14, "y": 0.87 }, "kind": "source-note", "text": "1. Kilpatrick, D., Resnick, H., Milanak, M., Miller, M., Keyes, K. and Friedman, M., 2013. National Estimates of Exposure to Traumatic Events and PTSD Prevalence Using DSM-IV and DSM-5 Criteria. Journal of Traumatic Stress, 26(5), pp.537–547; 2 Mayo LM, Asratain A., Lindé J et al. Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial. Biol Psychiatry. 2020 Mar 15; 87(6): 538-54\n2. Lee DJ, et al. Psychotherapy versus pharmacotherapy for posttraumatic stress disorder: systemic review and meta-analyses to determine first-line treatments. Depress Anxiety. 2016;33(9):792-806.\n3. US Census Bureau. https://www.census.gov/library/stories/2021/08/united-states-adult-population-grew-faster-than-nations-total-population-from-2010-to-2020.html", "attrs": { "numbered": true }, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "37d8754f-04e8-4a2a-8af6-02dbd27b508e", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.41, "x": 0.04, "y": 0.18 }, "kind": "title", "text": "PTSD Represents a Significant Unmet Need", "attrs": null, "subkind": "action-title", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "8272ee24-dad6-4001-a973-b1e27587c337", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.05, "w": 0.78, "x": 0.07, "y": 0.03 }, "kind": "title", "text": "PTSD: A Chronic Psychiatric Disorder with Significant Morbidity and Mortality", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "cce53908-6a00-4bfc-9254-cd4fc3830b41", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [ { "name": "Audience Definition", "slug": "audience-definition", "agent": "Storyteller", "layer": "slide", "matchId": "f9d9c2f6-53e7-429f-87a4-79e1e300808d", "evidence": "Patients may orient their careers around a narrow set of potential occupations and may struggle with job performance", "confidence": 0.5 }, { "name": "Problem Statement Canvas", "slug": "problem-statement-canvas", "agent": "Architect", "layer": "slide", "matchId": "3b0806fe-1505-42e5-a2f1-f9d6f77be56b", "evidence": "PTSD Represents a Significant Unmet Need", "confidence": 0.7 } ], "frameworks": [], "arcBeats": [ { "to": 11, "from": 8, "beatId": "e98c942b-e5ba-4e34-9076-9b609ceab426", "arcName": "Problem-Agitate-Solution", "arcSlug": "problem-agitate-solution", "beatName": "Solution (Provide relief)", "beatSlug": "problem-agitate-solution-solution-provide-relief", "evidence": "The deck presents BNC210 as a potential solution with a compelling rationale and promising results", "position": 2, "confidence": 0.8, "parentBeatName": "Resolution", "parentBeatSlug": "resolution" } ], "loops": [ { "to": 10, "from": 5, "name": "Cost Of Inaction", "slug": "27-cost-of-inaction", "bestFor": "Urgent budget requests, compliance, risk mitigation", "matchId": "78fc056c-ae43-4691-bb01-042247be6fe2", "evidence": "The deck highlights the significant unmet need and market opportunity", "position": 0, "objective": "What is the cost of not addressing anxiety disorders and PTSD?", "structure": "The Status Quo -> The Hidden Costs Accumulating -> The Future State of Inaction -> The Tipping Point", "confidence": 0.7, "description": "Quantify what happens if the audience does nothing" }, { "to": 11, "from": 8, "name": "Why Now", "slug": "15-why-now", "bestFor": "Sales pitches, fundraising, requesting immediate budget approval", "matchId": "061d4993-85b0-4818-8e44-b43269fb1025", "evidence": "The deck presents a compelling rationale for BNC210 in ongoing studies", "position": 1, "objective": "Why is now the right time for BNC210?", "structure": "The Context (Trends) -> The Trigger Event -> The Window of Opportunity", "confidence": 0.7, "description": "Create temporal urgency by proving that the window of opportunity is opening or closing" } ], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }